导语

  

    《中国医学院士文库》从文化出版与医疗卫生这两个行业的结合点上，准确地把握住了军地医务人员对弘扬医德医风、提升医疗技术的深层需求和期待，广大医务人员可以从中领略、学习到我国医学界名医大家不畏艰辛的奋斗历程、科学严谨的治学风范、勇于创新的学术精神、开阔深刻的思维品质。
    《周宏灏院士集(精)》作为丛书之一，充分诠释了周宏灏院士的学术成就、学术思想和学术风范，可供广大医学工作者学习、借鉴。

内容提要

  

    《周宏灏院士集》是《中国医学院士文库》的分册之一。本书由六部分组成。第一部分奋斗历程，介绍了院士的主要经历和事业发展的宝贵经验；第二部分学术贡献，包括院士的主要学术论文、学术著作以及学术年表等，反映了院士在理论创新和技术进步方面的主要成果及其价值；第三部分治学之道，阐述了院士的创新意识、严谨作风和刻苦精神；第四部分大师风范，记载了院士在培养人才和团队建设上为人师表的生动事例；第五部分社会影响，汇集了社会各界对院士学术成果和先进事迹的评价和赞誉；第六部分人生风采，以丰富的图片资料展示了院士在不同时期工作、讲学、国际交流、社会活动和业余生活等方方面面的风采。全书充分诠释了周宏灏院士的学术成就、学术思想和学术风范，可供广大医学工作者，特别是从事遗传药理学临床、科研、教学的专业人员学习、借鉴。

第一部分  奋斗历程
  中国遗传药理学的开拓者——记中国工程院院士周宏灏
第二部分  学术贡献
  一、周宏灏院士的学术成就与学术思想
  二、周宏灏院士的主要学术论文
    Single-Dose Pharmacokinetics of Ceftriaxone in Healthy Chinese Adults
    Racial Differences in Drug Response——Altered Sensitivity to and Clearance of Propranolol
    in Men of Chinese Descent as Compared with American Whites
    Interindividual Differences in β-receptor Density Contribute to Variability in Response
    to β-adrenoceptor Antagonists
    Induction of Polymorphic 4'-hydroxylation of S-mephenytoin by Rifampicin
    Quinidine Reduces Clearance of(+)-Propranolol More than(一)-Propranolol Through
    Marked Reduction in 4-Hydroxylation
    Differences in Plasma Binding of Drugs Between Caucasians and Chinese Subjects
    Increased Suppression of Exercise-Induced Increase in Renin by Propranolol in Chinese
    Subjects
    Lack of Effect of Ageing on the Stereochemical Disposition of Propranolol
    Differing Effect of Atropine on Heart Rate in Chinese and White Subjects
    Ethnic Differences in Response tO Morphine
    Stereoselective Disposition of Carvedilol is Determined by CYP2D6-
    The Elimination of Diazepam in Chinese Subjects is Dependent on the Mephenytoin
    Oxidation Phenotype
    In Vivo Inhibition of CYP2C19 But Not CYP2D6 by Fluvoxamine
    Genetic Polymorphisms of Debrisoquine and S-mephenytoin Oxidation Metabolism
    in Chinese Populations：a Meta-analysis
    Differences in the Incidence of the CYP2C19 Polymorphism Affecting the S-Mephenytoin
    Phenotype in Chinese Han and Bai Populations and Identification of a New Rare CYP2C19
    Mutant Allele
    Evidence for the Effect of Gender on Activity of (S)-Mephenytoin 4'-Hydroxylase
    (CYP2C19) in A Chinese Population
    Meta-analysis of Phenotype and Genotype of NAT2 Deficiency in Chinese
    Populations
    The Induction Effect of Rifampicin on Activity of Mephenytoin 4'-hydroxylase Related
    to M1 Mutation of CYP2C19 and Gene Dose
    Evidence for Involvement of Polymorphic CYP2C19 and 2C9 in the N-demethylation
    of Sertraline in Human Liver Microsomes
    Effect of the Gene Dosage of CYP2C19 on Diazepam Metabolism in Chinese
    Subjects
    Phenotypic Polymorphism and Gender-related Differences of CYP1A2 Activity in a
    Chinese Population
    5-Hydroxylation of Omeprazole by Human Liver Microsomal Fractions from Chinese
    Populations Related to CYP2C19 Gene Dose and Individual Ethnieity
    Ethnic Differences in Drug Metabolism
    Effect of the CYP2C19 Oxidation Polymorphism on Fluoxetine Metabolism in Chinese
    Healthy Subjects
    Pharmacokinetics of Sertraline in Relation to Genetic Polymorphism of CYP2C19
    Plasma Caffeine Metaboite Ratio (17X/137X) in Vivo Associated with G-2964A and
    C734A Polymorphisms of Human CYPIA2
    O-Dealkylation of Fluoxetine in Relation to CYP2C19 Gene Dose and Involvement
    of CYP3A4 in Human Liver Microsomes
    Assessment of Cytochrome P450 Activity by a Five-drug Cocktail Approach
    The Role of CYP2C19 in Amitriptyline N-demethylation in Chinese Subjects
    Inducibility of CYPIA2 by Omeprazole in Vivo Related to the Genetic Polymorphism
    of CYP 1A 2
    Phenotypic Polymorphism of CYP2A6 Activity in a Chinese Population
    Histamine N-methyltransferase Gene Polymorphisms in Chinese and Their Relationship
    with Enzyme Activity in Erythrocytes
    Isozyme-specific Induction of Low-dose Aspirin on Cytochrome P450 in Healthy
    Subjects
    Gly389Arg Polymorphism of β1-adrenergic Receptor is Associated with the
    Cardiovascular Response to Metoprolol
    Pharmacokinetics of Citalopram in Relation to Genetic Polymorphism of CYP2C19
    The Distribution and Gender Difference of CYP3A Activity in Chinese Subjects
    St John's Wort Induces Both Cytochrome P450 3A4一catalyzed Sulfoxidation and
    2C19-dependent Hydroxylation of Omeprazole
    liell8Val Genetic Polymorphism of CYP3A4 and Its Effects on Lipid-lowering
    Efficacy of Simvastatin in Chinese Hyperlipidemic Patients
    Gender Specific Association of CYP2C9’3 with Hyperlipidaemia in Chinese
    β1-Adrenergic Receptor Polymorphisms Influence the Response to Metoprolol
    Monotherapy in Patients with Essential Hypertension
    Effect of SL001B 1 Genetic Polymorphism on the Pharmacokinetics of Nateglinide
    Frequency of Genetic Polymorphisms of COX1，GP IIIa and P 2Y1 in a Chinese
    Population and Association with Attenuated Response to Aspirin
    SLC01B 1 521T→C Functional Genetic Polymorphism and Lipid-lowering Efficacy
    of Multiple-dose Pravastatin in Chinese Coronary H eart Disease Patients
    The Effect of Herbal Medicine Baicalin on Pharmacokinetics of Rosuvastatin
    Substrate of Organic Anion-transporting Polypeptide 181
    Hepatic Nuclear Factor l a Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics
    of the Organic Anion Transporting Polypeptide 181 Substrate Rosuvastatin and
    Bilirubin
    Effects of Ginkgo Biloba Extract on the Pharmacokinetics of Bupropion in H ealthy Volunteers
    Plant Polyphenol Curcumin Significantly Affects CYPIA2 and CYP2A6 Activity in
    Healthy．Male Chinese Volunteers
    Pharmacogenetics of Drugs Withdrawn from the Market-
  三、周宏灏院士的主要学术著作
    药理学
    Textbook of Pharmacology
    Case FilesTM Pharmacology
    Pharmacology
    遗传药理学(第2版)
  四、周宏灏院士重要学术报告、重要讲话
    Ethnic Differences in Drug Response
    Pharmacogenetic Research about Natural Medicine Effect of Natural Medicine on CYP450
    Ethnic Differences in Drug Metabolism
    Genetic Polymorphism of CYP2C19 in Chinese Populations
    Pharmacogenetics ant’i Pharmacogenomics in Asian Populations and Impaci on Clinical
    Pharmacology
    Racial Differences in Drug Response Reflect Differences in Distribution of Polymorphic
    Traits
    Pharmacogenetic and Pharmacogenomic Research in China
    Ethnicity，Genet：ics and Tailored Pharmacotherapy
    个体化药物治疗的研究与开发
    药物基因组学研究技术成果在药物临床评价中的应用
    在临床试验中不能忽视亚洲人群种族差异的基因多态性
    药物代谢酶基因多态性与个体化药物治疗
    个体化医学的实施与展望
    五、周宏灏院士学术年表
    周宏灏院士论文目录
    周宏灏院士专著目录
    周宏灏院士科研与教学成果目录
    周宏灏院士获国家发明专利目录
第三部分  治学之道
    勤勉严谨做学问  情系祖国育桃李
    遗传药理学研究的先行者
    善于发现  勇于挑战——访临床药理学家周宏灏院士
    中国遗传药理学开拓者周宏灏：立志如山  行道如水
    周宏灏：中国个体化用药的“拓荒者”
    让患者用药更精确
    用药也需“量体裁衣”——访我国著名遗传药理学家周宏灏教授
第四部分  大师风范
  一、感悟、经验与情怀
    做人做事做学问
    心系学子  桃李芬芳  以德服人从严治学
    医学教育不能硬套综合大学管理体制——中国工程院院士周宏灏谈我国医学教育现状与改革
    春蚕到死丝方尽，人至期颐亦不休
    我的情操
  二、部分学生的代表性论文
    Effect of Asymmet ric Dimethylarginine on OsteobIastic Differentiation
    Effect of SLCOIB1 Genetic Polymorphism on the Pharmacokinetics of Nateglinide
    Evidence for Involvement of Calcitonin Gene-Related Peptide in Nitroglycerin Response
    and Association with Mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) Glu504Lys
    Polymorphism
    Molecular Population Genetics of Human CYP3A Locus. Signatures of Positive
    Selection and Implications for Evolutionary Environmental Medicine
    Coupling HPLC to on-line, Post-column (bio) Chemical Assays for High-resolution
    Screening of Bioactive Compounds from Complex Mixtures
    KCNJ 11 Lys23Glu and TCFTL2 rs290487(C/T) Polymorphisms affect Therapeutic
    Efficacy of Repaglinide in Chinese Patients with Type 2 Diabetes
    Inhibition of the Organic Anion-transporting Polypeptide 1B1 by Quercetin: An
    in Vitro and in Vivo Assessment
    Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy
    by Regulating DNA Repair
    The Pregnane X Receptor Agonist St John's Wort Has No Effects on the Pharmacokinetics
    and Pharmacodynamics of Repaglinide
    Effects of Lignans Extracted from Eucornmia Ulmoides and Aldose Reductase Inhibitor
    Epalrestat on Hypertensive Vascular Remodeling
    ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese
    Epileptic Patients
    Theragnostics Meets Traditional Chinese Medicine: Rational Prediction of Drug-herb
    Interactions
    Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small
    Cell Lung Cancer (NSCLC) Patients
    Protective Effects of Eucommia Lignans Against Hypertensive Renal Injury by
    Inhibiting Expression of Aldose Reductase
    Translational Regulation of RPA2 Via Internal Ribosomal Entry Site and by eIF3a
    Effect of NR3C2 Genetic Polymorphisms on the Blood Pressure Response to Enalapril
    Treatment
    The KCNH2 Genetic Polymorphism (1956, C＞T) Is a Novel Biomarker That Is Associated
    with CCB and α, β-ADR Blocker Response in EH Patients in China
    Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
    Current Pharmacogenomic Studies on hERG Potassium Channels
    Deficiency of Multidrug and Toxin Extrusion 1 Enhances Renal Accumulation of
    Paraquat and Deteriorates Kidney Injury in Mice
    Effects of the PerOXisome Proliferator Activatedl Receptor-γ Coactivator-la (PGC-la)
    Thr394Thr and Gly482Ser Polymorphisms on Rosiglitazone Response in Chinese
    Patients with Type 2 Diabetes Mellitus
    Characterization and Analyses of Multidrug Resistance-associated Protein 1(MRP1／
    ABCC1) Polyrnorphisms in Chinese Population
第五部分  社会影响
    我学者首次发现不同种族对药物的差异性
    Effectiveness of Drugs May be Influenceol by Racial and Ethnic History
    深入了解中国人的心脏
    种族与药物的治疗效应
    β-受体阻滞药效应呈现种族差异
    药物效应的种族差异
    我国医学科技占世界之首成果巡礼
    Biolnedicine
    DNA Chips Bring Personalizeol Medicine to China
    开拓国际临床药理新领域——记中国工程院院士周宏灏
    世界首张个体化用药基因芯片初步研制成功
    个体化用药成为焦点
    用多少药，问问你的遗传基因
    基因芯片：有助于药物治疗个体化
    用药也可“量体裁衣”
    周宏灏教授当选世界药理学联合会药物代谢学会理事
    省儿童医院聘请周宏灏为终身首席科学家
    引领人类个体化用药新时代的人——记我国著名临床与遗传药理学家周宏灏教授
    研发一体化做强湖南医药产业——访中国遗传药理学专家、中南大学临床药理研究所
    所长、中国工程院院士周宏灏教授
    种族差异、遗传及个体化药物治疗
第六部分  人生风采
    成长历程
    教书育人
    学术交流
    珍贵合影
    人文情怀