导语
内容提要
本书旨在介绍磁性纳米材料的性质、控制合成与修饰方法及其在生物医学领域的应用。从纳米磁学的基本原理出发,介绍了磁性纳米材料的基本特性以及由此产生的潜在应用前景。以最具代表性的氧化铁纳米颗粒为例,详细介绍了其制备、表面修饰及生物医学应用潜力。进而基于磁性纳米材料及其复合物的优异性能与制备的可控性。书中重点总结了用于影像介导的可视化治疗的方法,并讨论了磁性纳米复合材料。
目录
Foreword
Preface
Introduction
Chapter 1 Nanomagnetism: Principles, Nanostructures, and Biomedical Applications
1.1 Introduction
1.2 Nanomagnetic effects
1.2.1 Single domain and superparamagnetism
1.2.2 Exchange-coupling effect
1.2.3 Exchange bias effect
1.3 Magnetism of nanomaterials
1.3.1 Magnetism of NPs
1.3.2 Magnetism of nanoplates
1.3.3 Magnetism of nanorings
1.4 Biomedical applications of nanomagnetism
1.4.1 T2 MRI contrast agents
1.4.2 Magnetic hyperthermia
1.4.3 Biosensors
1.5 Conclusion
References
Controlled Synthesis and Modification
Chapter 2 Chemical Synthesis of Magnetic Nanocrystals: Recent Progress
2.1 Introduction
2.2 Chemical synthesis of single-component magnetic NCs
2.2.1 Metal oxides
2.2.2 Metals and alloys
2.2.3 Metal carbides, phosphides, and chalcogenides
2.3 Chemical synthesis of multi-component magnetic NCs
2.3.1 Core/shell heterostructure
2.3.2 Oligomer-like heterostructure
2.3.3 Anisotropically shaped material-based heterostructure
2.4 Chemical synthesis of hollow/porous magnetic NCs
2.4.1 Fe-based hollow/porous NCs
2.4.2 Mn-based hollow/porous NCs
2.5 Summary and perspectives
References
Chapter 3 Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Coating Techniques for Biomedical Applications
3.1 Introduction
3.2 Fe3O4 and γ-Fe2O3
3.3 Size-induced magnetism evolution and application mechanisms
3.4 Synthesis approaches
3.4.1 Physical vapor deposition (PVD)
3.4.2 Chemical vapor deposition (CVD)
3.4.3 Electrodeposition
3.4.4 Hydrothermal
3.4.5 Co-precipitation
3.4.6 High-temperature (thermal) decomposition of organometallic precursors
3.5 Surface coating for biomedical application
3.5.1 Au coating
3.5.2 SiO2 coating
3.5.3 TaOx coating
3.5.4 Polymer coating
3.5.5 Small molecular coating
3.5.6 Carbon coating
3.6 Conclusions and perspectives
References
Chapter 4 Surface Modification of Magnetic Nanoparticles in Biomedicine
4.1 Introduction
4.2 Surface modification with organic molecules
4.3 Coating modification with macromolecules
4.3.1 Polymer coating
4.3.2 Liposome and micelle encapsulation
4.4 Coating modification with inorganic materials
4.4.1 Silica coating
4.4.2 Metal element coating
4.5 Conclusions and outlook
References
Diagnosis and Therapy
Chapter 5 Magnetic Nanoparticle-Based Cancer Nanodiagnostics
5.1 Introduction
5.2 Magnetic resonance imaging
5.3 Diagnostic magnetic resonance
5.4 Multifunctional MNPs for multimodal probing
5.5 Conclusion and future prospects
References
Chapter 6 Magnetic Microbubble: A Biomedical Platform Co-constructed from Magnetics and Acoustics
6.1 Introduction
6.2 Magnetic nanoparticles and magnetic characteristics
6.2.1 Preparation, surface modification, assembly of magnetic nanoparticles
6.2.2 Special features of magnetic nanoparticles
6.2.3 Biomedical applications of magnetic nanoparticles
6.2.4 Ultrasonic characteristics of magnetic nanoparticles liquid
6.3 Microbubble formalism and acoustic characteristics
6.3.1 Design and preparation of microbubbles
6.3.2 Actions of MBs with ultrasound waves
6.4 Magnetic and acoustic character of magnetic microbubbles (MMBs)
6.4.1 Fabrication of magnetic microbubbles
6.4.2 Acoustic response of magnetic microbubbles
6.4.3 Magnetic response of magnetic microbubbles
6.5 Applications of magnetic microbubbles in biomedicine
6.5.1 Multimodal imaging of MMBs
6.5.2 Ultrasound assisted drug delivery of MMBs
6.5.3 Magnetic field-controlled drug delivery and release of MMBs
6.6 Summary and perspectives
References
Chapter 7 Multifunctional Magnetic Nanoparticles for Magnetic Resonance Image-guided Photothermal Therapy for Cancer
7.1 Introduction
7.2 ICG-loaded MNPs for MR/fluorescence bimodal image-guided PTT
7.2.1 Fabrication of ICG-loaded SPIO NPs
7.2.2 In vivo MR/fluorescence bimodal imaging of ICG-loaded SPIO NPs
7.2.3 In vivo photothermal therapy with ICG-loaded SPIO NPs
7.3 Gold-nanoshelled magnetic cerasomes for MRI-guided photothermal therapy
7.3.1 Cerasomes combine the advantages of both liposomes and silica nanoparticles
7.3.2 Contrast-enhanced MRI imaging using GNMCs
7.3.3 Synergistic e.ect in killing cancer cells using GNMCs
7.4 Gold-nanoshelled magnetic nanocapsules for MR/ultrasound bimodal image-guided photothermal therapy
7.4.1 SPIOs-embedded PFOB nanocapsules with PEGylated gold shells (PGS-SP NCs)
7.4.2 Bimodal US/MRI contrast imaging capability of PGS-SP NCs
7.5 Conclusion and perspectives
References
Chapter 8 Magnetic-mediated Hyperthermia for Cancer Treatment: Research Progress and Clinical Trials
8.1 Cancer hyperthermia
8.2 Overview of magnetic-mediated hyperthermia (MMH)
8.2.1 Working mechanism and brief introduction to MMH
8.2.2 Categories of MMH
8.3 Research progress of MMH
8.3.1 IIH by thermoseeds and magnetic stent hyperthermia
8.3.2 AEH for liver cancer
8.3.3 Magnetic hyperthermia by MNPs
8.4 Clinical applications of MMH
8.4.1 Clinical trials of MMH by thermoseeds
8.4.2 Clinical trials of MSH
8.4.3 Clinical Trials of MNH
8.4.4 Clinical trials of AEH
8.5 Multifunctional magnetic devices for cancer multimodality treatment
8.5.1 Multifunctional magnetic device for thermoradiotherapy
8.5.2 Multifunctional magnetic devices for thermochemotherapy
8.6 Conclusions and remarks
References
Chapter 9 Magnetic Nanoparticle-based Cancer Therapy
9.1 Introduction
9.2 MNPs-based cancer therapy
9.2.1 Magnetic hyperthermia
9.2.2 Magnetic specific targeting
9.2.3 Magnetically controlled drug delivery
9.2.4 Magnetofection
9.2.5 Magnetic switches for controlling cell fate
9.2.6 Recently developed therapies
9.3 Conclusions and perspectives
References
Chapter 10 Composite Magnetic Nanoparticles: Synthesis and Cancer-related Applications
10.1 Introduction
10.2 Controlled synthesis of composite nanoparticles
10.2.1 Dumbbell-like nanoparticles
10.2.2 Core a shell nanoparticles
10.2.3 Core/satellite- or flower-like NPs
10.3 Applications
10.4 Summary and perspective
References
Chapter 11 Formation of Multifunctional Fe3O4/Au Composite Nanoparticles for Dual-mode MR/CT Imaging Applications
11.1 Introduction
11.2 Synthesis or formation of Fe3O4/Au CNPs
11.2.1 “Dumbbell-like" structured CNPs
11.2.2 “Core/shell" structured CNPs
11.3 Dual-mode MR/CT imaging applications of Fe3O4/Au CNPs
11.4 Concluding remarks and outlooks
References
Biocompatibility
Chapter 12 Using Magnetic Nanoparticles to Manipulate Biological Objects
12.1 Introduction
12.2 Protein separation
12.3 Magnetofection
12.4 Manipulation of cellular organelles
12.5 Separation and detection of bacteria
12.6 Manipulation of cells
12.7 Manipulation of organs
12.8 Conclusion
References
Chapter 13 Toxicity of Superparamagnetic Iron Oxide Nanoparticles: Research Strategies and Implications for Nanomedicine
13.1 Introduction
13.2 Mechanism of toxicity
13.3 In vitro cytotoxicity
13.4 In vivo toxicity of SPIONs
13.5 Blood compatibility
13.6 Biodistribution and elimination
13.7 In silico assays for nanotoxicity
13.8 Surface engineering for SPIONs-based nanomedicine
13.9 Conclusions and perspectives
References
Perspective
References