导语

  

内容提要

  

    魏冬青、马亦龙、曹志成、徐沁、周丰丰著的《转化生物信息学及其应用(英文版)(精)》系“转化医学出版工程：技术系列”之一，邀请了国内外生物、医学、信息学方面的专家学者介绍其最前沿的研究成果，从不同角度展现其研究过程中应用转化医学信息学相关方法或工具的实例，主要包括以下儿个方面：(1)组学数据分析协助精准医疗；(2)通过计算生物学方法，探索成药机制，指导药物研发；(3)计算机辅助药物发现，通过定向设计与虚拟筛选更为高效快速地使众多先导化合物向临床药物转化；(4)利用大数据，通过生物统计学、生物信息学和系统生物学方法研究复杂疾病；(5)生物成像及其他信息学技术在转化医学中的应用。本书实用性强，可极大地开拓基础和临床医学工作人员的思路。

Part I  Computer-Aided Drug Discovery
  1  Drug Discovery
    Geetha Ramakrishnan
  2  Translational Bioinformatics and Drug Discovery
    Pramodkumar Pyarelal Gupta
  3  Translational Research in Drug Discovery and Development
    Neha Arora, Pawan Kumar Maurya, and Puneet Kacker
  4  Exploring the Potential of Herbal Ligands Toward Multidrug-Resistant Bacterial Pathogens by Computational Drug Discovery
    Sinosh Skariyachan
Part II  Protein-Ligand Interactions and Drug Development
  5  The Progress of New Targets of Anti-HIV and Its Inhibitors
    Ke Z. Wu and Ai X. Li
  6  Recent Studies on Mechanisms of New Drug Candidates for Alzheimer's Disease Interacting with Amyloid-β Protofibrils Using Molecular Dynamics Simulations
    Huai-Meng Fan, Qin Xu, and Dong-Qing Wei
  7  Homology Modelling, Structure-Based Pharmacophore Modelling, High-Throughput Virtual Screening and Docking Studies of L-Type Calcium Channel for Cadmium Toxicity
    Madhu Sudhana Saddala and A. Usha Rani
  8  Natural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases:
    An In Silico and In Vitro Advancement
    Pushpendra Singh, Shashank Kumar, and Felix Bast
Part III  Omics for Precision Medicine
  9   Genome-Wide Association Studies: A Comprehensive Tool
    to Explore Comparative Genomic Variations and Interactions
    Aruni Wilson
  10  A Survey of Bioinformatics-Based Tools in RNA-Sequencing
    (RNA-Seq) Data Analysis
    Pallavi Gaur and Anoop Chaturvedi
  11  Epigenetics and Its Role in Human Cancer
    Utkarsh Raj and Pritish Kumar Varadwaj
  12  Methods for Microhiome Analysis
    Kalibulla Syed Ibrahim and Nachimuthu Senthil Kumar
  13  Pharmacogenomics: Clinical Perspective, Strategies,and Challenges
    Dev Bukhsh Singh
Part IV  Biostatistics, Bioinformatics, and System Biology Approaches to Complex Diseases
  14  Computational Network Approaches and Their Applications for Complex Diseases
    Ankita Shukla and Tiratha Raj Singh
  15  Bioinformatics Applications in Clinical Microbiology
    Chao Zhang, Shunfu Xu, and Dong Xu
Part V  Bioimaging and Other Applications of Informatics Techniques in Translational Medicine
  16  Artificial Intelligence and Automatic Image Interpretation in Modern Medicine
    Costin Teodor Streba, Mihaela Ionescu, Cristin Constantin Vere, and Ion Rogoveanu
  17  Computation in Medicine: Medical Image Analysis and Visualization
    Adekunle Micheal Adeshina
Index