导语

  

内容提要

  

    巴嘎万根据教育部相关文件规定，为满足医学院校临床医学专业双语教学和来华留学生教学的需要，在调研、论证的基础上组织编写《生物化学(供临床医学专业及来华留学生MBBS双语教学用改编教学版全国高等学校教材)(英文版)》。本教材为英文版规划教材，在引进外版教材的基础上，根据我国教学实际情况进行改编，以使知识体系和主要内容基本符合教学大纲的要求。

Section I Structure and Function of Biomolecules
Chapter I Structure and Function of Protein
L-a-AMINO ACIDS: STRUCTURE
CLASSIFICATION
Nonpolar Amino Acids
Acidic Amino Acids
Basic Amino Acids
Neutral Amino Acids
ELECTROLYTE AND ACID-BASE PROPERTIES
THREE-DIMENSIONAL STRUCTURE OF PROTEINS AND DISORDERS OF
PROTEIN MISFOLDING
COVALENT AND COORDINATE COVALENT BONDS IN PROTEIN STRUCTURE
NONCOVALENT INTERACTIONS IN PROTEIN STRUCTURE
Attractive Forces
Repulsive Forces
PRIMARY STRUCTURE
Peptide Bond
SECONDARY STRUCTURE
α-Helix
β-Pleated Sheet
β-Turns
Random Coil
Other Types of Secondary Structures
Motifs and Domain
TERTIARY STRUCTURE
QUATERNARY STRUCTURE
DENATURATION
CONVERSION OF PRECURSOR PROTEINS TO ACTIVE PROTEINS BY PROTEOLYSIS
PROTEIN FOI,DING AND INTRACEI.I.III,AR DEGRADATION OF MISFOLDED AND
DEFECTIVE PROTEINS
AUTOPHAGY
Proteolysis (Protein Degradation) by ATP-Dependent Ubiquitin-Proteasome Complex
Components and the Properties of the Ubiquitin-Proteasome System
PROTEIN MISFOLDING AND FIBRILLOGENIC DISEASES
Transmissible Spongiform Encephalopathies
Alzheimer's Disease
Chapter 2 Structure and Function of Nucleic Acids
STRUCTURE AND FUNCTION OF DNA
Discovery of DNA as the Genetic Material
Components of DNA
Base Pairing of Bases in DNA Double Helixes
Phosphodiester Backbone of DNA
Modifications of DNA Bases
Physical and Chemical Structure of DNA
Conformational Changes of the DNA Double Helix
DNA Supercoils
Denaturation of DNA
Renaturation of DNA
CHROMOSOMES AND CHROMATIN
Repetitive DNA Sequences
Restriction Enzymes
Nucleic Acid Hybridization
STRUCTURE AND FUNCTION OF RNA
Messenger RNA
Transfer RNA (tRNA)
Ribosomal RNA (rRNA)
Other Noncoding RNAs
Chapter 3 Enzymes
NOMENCLATURE
CATALYSIS
Specificity of Enzyme Catalysis
ACTIVE SITE AND ENZYME-SUBSTRATE COMPLEX
Factors Governing the Rate of Enzyme-Catalyzed Reactions
MICHAELIS-MENTEN MODEL FOR ENZYME-CATALYZED REACTIONS
Linear Plots for Michaelis-Menten Kinetic Behavior
INHIBITION
Reversible Inhibition
Reversible Inhibition: Examples in Single-Substrate Reactions
Reversible Inhibition by Reaction Products
Reversible Inhibition by Metal Ion Substitution
IRREVERSIBLE INHIBITION
……
Section II Substance Metabolism
Section III Transmit of genetic information
Section IV Special Topics